Building the World's First Non-Invasive Brain-to-AI Interface

Strange Loop Neurosciences is a research lab pioneering novel BCI paradigms and developing non-invasive interface systems to connect human cognition directly to artificial intelligence, all without surgery.

Est. 2024

"In the end, we self-perceiving, self-inventing, locked-in mirages are little miracles of self-reference."

Douglas Hofstadter, I Am a Strange Loop

1st

Non-Invasive B2AI

Publications

Patents Filed

2024

Founded

Our Approach

Changing the Paradigm

Modern brain-computer interface paradigms overlook a key aspect of the Strange Loop of the human organism. Biology is agentic. Malleable. Trainable. By combining cutting-edge engineering and neurotech with mastery of behavioral and cognitive conditioning, we unlock novel applications far exceeding the status quo.

In 2025, we demonstrated the world's first non-invasive B2AI, connecting the human brain directly to an LLM. Now, we are engineering new ways to put more of our biology under conscious control.

Research

Expanding the Realm of Conscious Control
by Engineering Strange Loops

Our research pushes the boundaries of what is possible in brain-computer interfacing, laying the groundwork for a new approach to Human-AI integration. We coined the terms B2AI (Brain-to-AI Interface), Therapeutic Neural Reinforcement (TNR), and BasCI (Basal Cognitive Interfacing) to encapsulate the full scope of our paradigm.

01 — B2AI

Brain-to-AI Interfacing

We are building the world's first non-invasive brain-to-AI interfaces, systems that allow direct two-way communication between the human brain and an AI agent. No implants. No surgery. Just a wearable device that connects your cognition directly to AI, unlocking new heights of processing power.

Non-Invasive Real-Time Decoding Wearable LLM Integration

02 — TNR

Therapeutic Neural Reinforcement

The brain is not a static organ - it rewires itself in response to structured feedback. Our TNR program leverages this plasticity through precision neurostimulation, operant conditioning, and closed-loop biofeedback to open new applications for biological interfacing spanning cognitive resilience, performance optimization, rehabilitation, and beyond.

Neurostimulation Operant Conditioning Closed-Loop Feedback Neural Plasticity

03 — BasCI

Basal Cognitive Interfacing

The same principles driving cognition in the human nervous system have been shown to be at play in non-neural tissue. Altering bioelectric state can modify organism shape, enhance wound healing, and even kick-start regeneration in non-regenerative species. If cognition is a spectrum that exists below the brain, then our interfaces should extend there too.

Bioelectric Networks Basal Cognition AI-Automated Protocols Wound Healing & Regeneration

Bioelectric control of regenerative outcomes in planaria

Our Offerings

What We Offer

We build custom brain-to-AI systems and support the research ecosystem around them - from initial concept through published results.

B2AI

Custom Brain-to-AI Interfaces

We design and build bespoke non-invasive brain-to-AI interface systems tailored to your application. Whether you need a research prototype or a purpose-built system for a specific cognitive task, we handle the full pipeline - hardware selection, signal processing, AI model training, and integration. You define the problem; we deliver a working B2AI.

All custom B2AI systems are investigational research devices intended for use in controlled research settings only. They are not medical devices. They have not been evaluated, cleared, or approved by the FDA or any regulatory body. They are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Purchasers are responsible for ensuring use complies with all applicable institutional, local, and federal regulations.

Design

Research Design

Rigorous experimental design is the foundation of credible neuroscience. We help labs, startups, and institutions architect BCI, neurotech, and human subjects research studies from the ground up - participant protocols, IRB strategy, signal acquisition pipelines, statistical frameworks, and control conditions. We bring deep expertise in both the neuroscience and the engineering, so your study design accounts for the realities of both.

Pubs

Publication Support

Getting from data to published paper is its own discipline. We provide end-to-end publication support - manuscript drafting, figure design, statistical review, journal selection strategy, and response to reviewers. Whether you're targeting Nature Neuroscience or a specialized BCI journal, we help you tell your story with clarity and precision.

Get Started

Ready to Connect?

Reach out to discuss how we can support your next project - from a custom B2AI build to getting your research published.

Founder

Scientist-Built, Mission-Driven.

Patrick Seebold, Ph.D.

Founder & CEO

Founder Patrick Seebold holds a PhD in Psychology and a Master's in Statistical Genetics - a rare combination of training that bridges neurostimulation, engineering, and quantitative biology.

Dr. Seebold trained in Transcranial Magnetic Stimulation (TMS) at the Duke University School of Medicine, and has a track record of over $650,000 in awarded funding, with successful grants written for the National Science Foundation (NSF), the Foresight Institute, the Comparative Medicine Institute, and corporate partners.

This work is deeply personal. A family member spent years battling a tumor of the brainstem, providing Dr. Seebold a front-row seat to the fragility and extraordinary adaptability of the human brain. This experience informs what we do at Strange Loop Neurosciences: develop systems that work with the brain and biology to promote wellness, health, and prosperity.

Classically-trained Pianist. Runner of Marathons. Self-taught Audio Engineer.

Collaborate

Work With Us

Strange Loop Neurosciences is actively seeking research collaborators, institutional partners, and exceptional scientists who want to shape the future of Human-AI co-evolution.

Get in Touch